The Canada-born 48-year-old replaces Ignacio Ambriz who resigned mid-week as Johan Cruyff's influence grows at the club since his appointment as consultant in February.
"The company responsible for the Chivas sporting project, headed by Johan Cruyff, has chosen John van't Schip to fill the post of coach from the next Apertura championship," Guadalajara said in a statement.
Van't Schip, a former Ajax and Genoa winger who was a member of the Netherlands' European Championship-winning squad in 1988, has worked as an assistant coach at Ajax and with the Dutch national team. He has also coached Twente Enschede and Australia's Melbourne Heart.
Guadalajara are Mexico's most popular and successful club with 11 league titles, their last in the 2006 Apertura.
