Atletico, on the verge of regaining the trophy they last won in 1996, head into Sunday's trip to Levante four points clear of Barcelona with three matches remaining and six ahead of city rivals Real Madrid, who have a game in hand.
And, after joining Real in the UEFA Champions League final with 3-1 win at Chelsea on Wednesday, the sky-high mood around the Vicente Calderon could be lifted further with the league title in sight for Diego Simeone's men.
That unlikely prospect coming to fruition would leave Atletico with a nervous wait to see if Valencia can obtain a surprise win at Real later on Sunday that would see Simeone's charges clinch the title.
But the chances of Real following up Tuesday's 4-0 (5-0 agg) Champions League semi-final triumph against Bayern Munich by potentially falling nine points adrift of Atletico with a home reverse to Valencia look to be remote.
Real's magnificent victory at the Allianz Arena keeps them in contention to win the European Cup for a 10th time. And they will need no extra motivation to maintain their hopes of the treble with a win over Juan Antonio Pizzi's men.
Ernesto Valverde's men will seal a place in Europe's premier club competition with three points regardless of Sevilla's result at Villarreal.
