The fourth round draw was short on blockbuster ties but the clash between a club still climbing off the canvas after a spectacular fall from grace since reaching the Champions League semi-final in 2001, and one with a massive Cup pedigree, will guarantee an old-fashioned atmosphere at White Hart Lane.
Tottenham manager Harry Redknapp, whose side lost 2-0 at Liverpool on Wednesday, can never be accused of taking the Cup lightly and will have his sights set on a May afternoon at Wembley.
"Cup final day is the best day of the year for me," Redknapp, who won the competition with Portsmouth in 2008, told www.thefa.com.
"When I was growing up, everyone looked forward to watching the Cup final. For me, it will always have great importance and I know what it means."
With Jermaine Beckford's goal having dispatched 11-times winners United and seven-times winners Liverpool humbled by Reading, two of English football's big four have already bitten the dust.
"It gives you a better chance with two of the big guns out," Redknapp added. "But we've drawn a team in Leeds which will present a difficult game for us.
"I know just how hard it's going to be. They were fantastic that day at Manchester United, their work rate and the way they played, they looked more like a Premier League team than a League One team."
Leeds's joy at beating United was tempered by league slip-ups against Wycombe Wanderers and Exeter City but they have been boosted by the news that the prolific Beckford is staying at Elland Road, despite interest from Everton.
"It's another away draw for us," Leeds manager Simon Grayson told the club's website.
"But we'll take great confidence from our win at Manchester United."
The competition's lowest placed survivors, League Two Accrington Stanley, have a dream tie at home to top flight Fulham.
"Financially it's a great boost for us," manager John Coleman told BBC radio. "I'd like to think we'd have a bumper crowd on Saturday. My lads have given everything all season."
