Zinedine Zidane’s side secured the win they needed against Borussia Monchengladbach in midweek to progress to the last 16 of the Champions League and relieve some pressure on the coach.
But the Merengues, who went into the weekend in fourth place, could risk losing sight of their neighbours if they are defeated on home turf.
Zidane will be without the services of the injured Eden Hazard and Luka Jovic and Martin Odegaard is a doubt, but Sergio Ramos made his comeback in midweek.
Atleti have injury issues of their own with Jose Gimenez, Diego Costa and Manu Sanchez on the sidelines.
Simeone’s side must overcome a poor run in this fixture, which they haven’t won since February 2016. But four of the last seven league meetings ended in a draw.
Kick-off is at 8.00pm GMT and the game is being shown on La Liga TV in the UK. See below for watching details where you are.
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Use a VPN to watch a Real Madrid v Atletico Madrid live stream from outside your country
If you’re on holiday or just simply out of the country, your domestic on-demand services won’t work – the broadcaster knows exactly where you are from your IP address. Your access to the game will be automatically blocked, which is annoying if you’ve paid a subscription fee and don't want to use an illegal, buffering stream that makes you miss another Bukayo Saka assist. And that's where we recommend ExpressVPN (more on which below).
All you need to do is get a Virtual Private Network (VPN) to get beyond such aggravations (assuming it complies with your broadcaster’s T&Cs). A VPN creates a private connection between your device and the internet, meaning suppliers can’t work out where you are and what you’re doing. The info going to and from is entirely encrypted.
There are plenty of options out there, including:
(Image credit: ExpressVPN)
ExpressVPN
Including a 30-day, money-back guarantee
Runs on almost any platform
Enterprise-level encryption
Speedy VPN servers in 94 countries
Superb 24/7 live customer support
Fewer simultaneous connections than some
FourFourTwo’s brainy office mates TechRadar love its super speedy connections, trustworthy security and the fact it works with Android, Apple, Roku, Amazon Fire TV, PS4 and loads more. You also get a money-back guarantee, 24/7 support and it's currently available for a knockdown price. Go get it!
(Image credit: NordVPN)
NordVPN
Including a 30-day, money-back guarantee
Quality mobile and desktop clients
Up to six connections and value pricing
Great performance in our tests
Not the best user experience at all times
Some historic security breaches
A cheaper option; its cheapest package current averages at a wallet-friendly £2.29 per month.
(Image credit: IPVanish)
IPVanish
Including a 30-day, money-back guarantee
Owns and manages its own servers
peedy live chat support
Powerful, configurable apps
Excellent download speeds
The odd usability issue
Slightly more expensive but supports up to 10 devices, and you can pay for it every three months if you need to.
How to watch a Premier League live stream in the UK
Sky Sports and BT Sport are the two main players once again, but Amazonalso have a slice of the pie in 2019/20.
If you don’t want to commit to a monthly contract, then NOW TV are currently offering up their Sky Sports Monthly Pass for just £9.99 (usual price £16.99) – it'll get you access to all of their Premier League and Football League offerings, including this game. Hurry, though: this offer ends at 23:59 BST on September 30.
How to watch a Premier League live stream for US subscribers
NBC Sports and Telemundo are the Premier League rights holders (in English and Spanish respectively). The Premier League Pass will give you 380 matches live to stream on-demand, plus shows highlights, analysis and on-demand replays for $64.99. For a cheaper alternative, the Matchday Pass showcases 140 live games for $39.99.
Head back to our VPN advice so you can take advantage when you're out of the country.
How to watch a Premier League live stream for Canadian subscribers
DAZN subscribers can watch every single Premier League game in 2019/20 – and it gets better. After a one-month free trial, you'll only have to pay a rolling $20-a-month fee, or make it an annual subscription of $150.
Want in while you're out of Canada? Scroll back up and check out the VPN offers above.
How to watch a Premier League live stream for Australian subscribers
Optus Sport are offering every game of the Premier League season for just $14.99/month for non-subscribers, which you can get via your Fetch TV box and all of the other friendly streaming devices.
To take advantage while you're not Down Under, follow the VPN advice towards the top of this page.
How to watch a Premier League live stream for New Zealand subscribers
Spark Sportare serving up all 380 games – plus various highlights and magazine shows throughout the week – for $19.99 a month, after a one-month trial.
It's also available via web browsers, Apple/Android devices, Google Chromecast and some Samsung TVs; Apple TV and Smart TV compatibility should be coming later in the year.
Check out our VPN deals to watch when you’re not in New Zealand.
How to watch a Premier League live stream for Malaysian subscribers
Astrohas secured Premier League rights for three seasons from 2019/20, and have every game available for viewing.
How to watch a Premier League live stream for Singaporean subscribers
You can watch all matches live with Singtel's Sports Plus, with current non-contract deal from $49.90.
For tips on how to view when you're out of the country, scroll back up for our VPN offers.
