Schweinsteiger was banned for one game after being booked in the 3-0 win over Kazakhstan in Astana on Friday. He opened the scoring in that match while Draxler was taken off in the 19th minute following a clash with an opponent.
"The suspicion of concussion was confirmed on Saturday," the team said in a statement before adding the player had left the squad's base in Bavaria.
Coach Joachim Low's Germany are five points clear of second-placed Sweden in Group C with 13 points from five matches.
Sweden, who drew 0-0 with Ireland on Friday, have eight points from four games.
Borussia Dortmund's Bender missed Friday's game with flu.
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