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Roma midfielder Daniele De Rossi suffered a calf injury during Wednesday's Champions League defeat against Real Madrid and is facing a four-week lay-off.
De Rossi made his return from a calf problem in the 2-0 loss at the Stadio Olimpico this week as he came off the bench for the final 13 minutes.
"For the Giallorossi midfielder, who this season has made 25 appearances and scored three goals, the estimated prognosis for a return is around four weeks," the club said in a statement.
De Rossi looks set to miss five games, including a Serie A clash with third-placed Fiorentina and the return leg of Roma's last-16 tie with Madrid at the Santiago Bernabeu.
