Premier League preview: What (definitely) will and won't happen

Manchester City can claim the title with victory over Manchester United, while Everton host Liverpool to kick off a big weekend of action

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Everton vs Liverpool (Saturday, 12.30pm)

The big talking point: The second Merseyside derby of the season. Everton were extremely fortunate to take a point at Anfield – under controversial circumstances too – so Liverpool will be determined to enforce their superiority on this one.

What will happen: You do just wonder how the Reds will respond after Wednesday night's thumping of Manchester City. They were so good, so energetic and so full of adrenaline that, just three days on, there will presumably be a cost to pay.

What won't happen: But that doesn't necessarily mean dropped points. Ordinarily, Goodison Park is a difficult, hostile place for Liverpool, but this season being what it has, that's unlikely to be the case. The crowd will still be into it, of course, but most Evertonians just seem eager for the year to end.

Bournemouth vs Crystal Palace (Saturday, 3pm)

The big talking point: The time is now for Palace: Huddersfield are in appalling form, Stoke and Southampton both have difficult games, so three points would go a long way towards survival.

What will happen: Expect Palace's good performances to continue. The trouble is, though, that while they've played well, they've been unable to take points from those games. They should have drawn with Tottenham, probably should have beaten Liverpool, and should have taken at least something from their game with Manchester United.

What won't happen: Eddie Howe's team are basically safe. That doesn't mean that they'll be pushovers, however. Howe is admirable in many ways - he's done a super job at Dean Court while also growing as a manager and a tactician - and those high performance standards he sets are part of this team's identity. They've lost just twice in the league since Christmas.

Brighton vs Huddersfield (Saturday, 3pm)

The big talking point: Outside of the two derbies, this is probably the biggest game of the weekend: a Brighton win leaves them virtually safe, while another defeat for Huddersfield and the future will look bleak indeed.

What will happen: Brighton win. David Wagner is generally excellent, but perhaps he's been too accepting of his side's inferiority this season? Huddersfield, particularly since the turn of the year, have too often been docile and - actually - now look absolutely shattered as a side. They've won just twice in the league in 2018; clearly, that's relegation form.

What won't happen: Anthony Knockaert serves the final game of his ban, while Dale Stephens is an injury doubt for Brighton. The extent of Elias Kachunga's injury was revealed this week and Huddersfield will have to do without him for the rest of the year.

Leicester vs Newcastle (Saturday, 3pm)

The big talking point: Not quite a dead-rubber, because Leicester can still secure a European place, but Newcastle aren't far away from safety now.

What will happen: If Leicester do qualify for the Europa League, that will be some result for Claude Puel. Remember all the bleating when he was appointed? Well, you don't hear much of that anymore - he's done an excellent job.

What won't happen: There'll be no Wilfred Ndidi (suspended), and that will certainly take something away from Leicester's midfield. Matty James is out for the season too, so Adrien Silva will likely start in central midfielder with Vicente Iborra, while Newcastle's Islam Slimani is ineligible to face his parent club.

Stoke vs Tottenham (Saturday, 3pm)

The big talking point: Stoke are running out of time. They enjoyed some good moments against Arsenal, but their lack of a forward eventually caught up with them. They have to find goals from somewhere.

What will happen: Tottenham must beware the day after the night before. They were excellent against Chelsea, fully deserving their points, but this is obviously a trap of a game and Mauricio Pochettino's team will have to ensure that a desperate Stoke aren't taken too lightly.

What won't happen: Again, there'll probably be no Toby Alderweireld. That situation grows ever more opaque and don't expect clarity any time soon. Davinson Sanchez and Jan Vertonghen will start as the centre-back pairing; Harry Kane should return after injury confined him to the bench last weekend.