Premier League preview: What (definitely) will and won't happen this weekend

Southampton fans

Arsenal travel to Old Trafford, while there's win-or-bust situations for Southampton and Stoke ahead

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Liverpool vs Stoke (Saturday, 12.30pm)

The big talking point: Liverpool still have a top-four place to secure, but the story is really Stoke: defeat here won't relegate them, but it might as well. They have to get something.

What will happen: We'll see the limitations of this Stoke team. They should have beaten West Ham. They should have beaten Burnley. They should have at least drawn with Spurs. They did none of those things, though, suffering from their inability to convert pressure into goals. It's hardly an original observation, but the lack of a reliable goalscorer has proven crippling.

What won't happen: Some good news for Paul Lambert, though: Liverpool will rotate their side and will definitely be without Alex Oxlade-Chamberlain and Sadio Mané, both of whom were midweek casualties. Oxlade-Chamberlain is now gone for the season - and the World Cup - but Mané should be fit for the trip to Rome and beyond.

Burnley vs Brighton (Saturday, 3pm)

The big talking point: A win for Brighton, coupled with a defeat for Southampton, would secure survival for Chris Hughton's team – a deserved reward for having conceded fewer goals than every other side in the bottom half of the table.

What will happen: The Manchester United/Chelsea FA Cup final means that seventh place in the league will now definitely carry Europa League qualification. The other good news for Sean Dyche and Burnley is that a single point will guarantee them that place.

What won't happen: An away win looks a remote possibility. Brighton haven't actually won away from home since November (1-0, Swansea) and they've only scored four goals away from the Amex since the turn of the year.

Crystal Palace vs Leicester (Saturday, 3pm)

The big talking point: This is the game Palace have been waiting for. Win here and they won't quite be safe, but it would require a strange sequence of events for them not to be. Three more points and Roy Hodgson will likely have completed an admirable comeback, despite probably the worst injury list in the division.

What will happen: And they'll get that win. Palace are actually in good form, having won two of their last four games and losing just once to Liverpool. Leicester? The energy drained from their season some time ago and it wouldn't be a great shock to see them roll over here. One team has a desperate need, the other none at all: that kind of disparity often tells in the score.

What won't happen: Palace continue to labour under their injury list - Jeff Schlupp is unavailable again against his former club - while Kasper Schmeichel is out for Leicester; as is Shinji Okazaki.

Huddersfield vs Everton (Saturday, 3pm)

The big talking point: Christ, won't this be negative. Huddersfield, never knowingly over-ambitious, against Sam Allardyce's Everton. What a spectacle.

What will happen: Goalless draw. Huddersfield's need isn't desperate – their win over Watford lifted them clear of immediate danger – and David Wagner isn't prone to reckless, over-committing football. Everton's season has never even really begun. They were only marginally less dreadful than Newcastle on Monday night, and they'll likely be content to sit behind the ball and take a point.

What won't happen: Morgan Schneiderlin suffered a dead leg in that 1-0 win at Goodison Park and seems set to miss out here.

Newcastle vs West Brom (Saturday, 3pm)

The big talking point: D-Day for West Brom: this is when the music stops. Depending on how other results go, even a win might not be enough to delay the inevitable.

What will happen: It should become 12 unbeaten games from 13 for Newcastle. West Brom produced a worthy comeback against Liverpool – at least their players want to play for Darren Moore – but the futility of their task should catch up with them. St James' Park will be vibrant, Newcastle will chase the point they need for safety, and West Brom will almost certainly wilt.

What won't happen: Christian Atsu is out, but Rafael Benitez has no fresh injury concerns. West Brom, too, will name the same squad which salvaged that point last weekend.