Inter welcome back Samuel and Ranocchia
The two players were injured during the 3-1 win at Juventus a fortnight ago and, according to La Repubblica, could both be in the squad for the clash.
Inter, who have struggled with injuries this season, will have to do without attacker Freddy Guarin after he suffered a thigh strain during their 3-2 defeat at Atalanta last Sunday.
However, they have also welcomed back midfielders Philippe Coutinho and Wesley Sneijder, who took part in training on Wednesday.
Coutinho could be in the squad to face Cagliari, although it is unlikely that Dutch international Sneijder will play any part.
Andrea Stramaccioni's side are in second place in Serie A, four points behind champions and leaders Juventus.