Italy striker Osvaldo, who has been at the centre of a penalty controversy after stealing a spot-kick from Francesco Totti and missing it during their 3-1 defeat at Sampdoria last Sunday, missed training on Friday with a right knee injury, Sky Sport 24 reported.
Midfielder De Rossi is suffering from a knock to his left thigh and is undergoing a special training schedule to get him ready for the clash.
Roma are ninth in Serie A with 34 points from 24 games, 21 points behind champions Juve.
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